The Islet Replacement Research Foundation is a voluntary nonprofit grantmaker and supporter of diabetes research. Its goal is to bring together dedicated scientists who support ambitious research projects to find a cure for diabetes and stamp out insulin dependence without the use of immunosuppressive drugs.

The Foundation raises funds through gifts from individual and corporate donors, special giving programs, events, and grants. The Foundation promotes scientific research by making strategic investments in research that moves closer to finding a cure for Type 1 Diabetes. The IRRF focuses its funding on investigator-initiated proposals that are on the cutting edge of research.